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    TLR3

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    Anti-TLR3 Products

    • Rabbit Anti-TLR3 Antibody (MOB-0272MC)
      • Species Reactivity: Human, Mouse, Rat, Avian, Bovine, Chicken, Opossum, Primate
      • Application: WB, FACS, IHC-P
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
    Protein class

    CD markers, Disease related genes

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Early spermatids, Distal enterocytes)

    Immune cell specificity

    Immune cell enhanced (memory CD8 T-cell, gdT-cell)

    Cell line specificity

    Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, CAPAN-2, HDLM-2, HSkMC)

    Interaction

    Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes (PubMed:33432245). Interacts with SRC; upon binding of double-stranded RNA. Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C) (PubMed:25736436).

    Molecular function

    Receptor, RNA-binding

    More Types Infomation
    Related Signaling Pathways
    NLR Signaling Pathway NLR Signaling Pathway
    TLR Signaling Pathway TLR Signaling Pathway
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