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TLR3

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Anti-TLR3 Recombinant Antibody Products

  • Rabbit Anti-TLR3 Antibody (MOB-0272MC)
    • Species Reactivity: Human, Mouse, Rat, Avian, Bovine, Chicken, Opossum, Primate
    • Application: WB, FACS, IHC-P
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For Research Use Only. Not For Clinical Use.


TLR3 is an endosomal Toll - like receptor mainly expressed on dendritic cells, macrophages, and some epithelial cells. It specifically recognizes double - stranded RNA (dsRNA), which is a common intermediate in the replication cycle of many viruses. Upon binding to dsRNA, TLR3 recruits the adaptor protein TRIF. This interaction triggers a signaling pathway that leads to the production of type I interferons (IFN - α and IFN - β) and other pro - inflammatory cytokines. Type I interferons play a crucial role in the antiviral response by inhibiting viral replication and activating immune cells to clear the infected cells.
Protein class

CD markers, Disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Early spermatids, Distal enterocytes)

Immune cell specificity

Immune cell enhanced (memory CD8 T-cell, gdT-cell)

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, CAPAN-2, HDLM-2, HSkMC)

Interaction

Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes (PubMed:33432245). Interacts with SRC; upon binding of double-stranded RNA. Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C) (PubMed:25736436).

Molecular function

Receptor, RNA-binding

More Types Infomation
Related Signaling Pathways
NLR Signaling Pathway NLR Signaling Pathway
TLR Signaling Pathway TLR Signaling Pathway
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