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TM4SF5
Anti-TM4SF5 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Paneth cells, Hepatocytes, Intestinal goblet cells, Enteroendocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CACO-2, Hep G2, OE19)
Interaction
Interacts with MTOR; the interaction is positively regulated by arginine and is negatively regulated by leucine (PubMed:30956113). Interacts with SLC38A9 (PubMed:30956113). Interacts with SLC7A1; the interaction is negatively regulated by arginine (PubMed:30956113). Interacts with CASTOR1; the interaction is positively regulated by leucine and is negatively regulated by arginine (PubMed:30956113).
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