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For Research Use Only. Not For Clinical Use.
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Heterodimer with BUD23/WBSCR22; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23 (PubMed:25851604, PubMed:34948388). Heterodimer with N6AMT1/HEMK2; this heterodimerization is necessary for S-adenosyl-L-methionine-binding to N6AMT1/HEMK2 (PubMed:20308323, PubMed:25851604, PubMed:31632689, PubMed:31636962, PubMed:31061526, PubMed:34948388). Heterodimer with ALKBH8 (PubMed:20308323, PubMed:34948388). Heterodimer with METTL5; this heterodimerization is necessary for the stability of the catalytic subunit METTL5 (PubMed:34948388, PubMed:32217665, PubMed:33428944, PubMed:35033535, PubMed:31328227). Interacts with THUMPD3; the interaction is direct and is required for THUMPD3 methyltransferase activity (PubMed:34948388, PubMed:34669960). Interacts with THUMPD2 (PubMed:34948388). Interacts with TRMT11 (PubMed:34948388).