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TUBB2B
Anti-TUBB2B Recombinant Antibody Products
- AbPlus™ Anti-TUBB2B Magnetic Beads (Mix-mA) (VS-0424-XY267)
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- Target: TUBB2B
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Anti-TUBB2B Immunohistochemistry Kit (VS-0325-XY2393)
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- Species Reactivity: Human, Mouse, Rat
- Target: TUBB2B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Muller glia cells, Horizontal cells, Distal tubular cells, Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, CACO-2, NTERA-2, RPMI-8226, SCLC-21H, SH-SY5Y, SuSa)
Interaction
Dimer of alpha and beta chains (PubMed:23001566, PubMed:28013290, PubMed:26732629). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
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