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For Research Use Only. Not For Clinical Use.
Cancer-related genes
Intracellular
Cell type enhanced (Adipocytes, NK-cells)
Low immune cell specificity
Cell line enhanced (ASC TERT1, HSkMC, hTCEpi, hTERT-RPE1)
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.