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UNG

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For Research Use Only. Not For Clinical Use.


Background

ung, or Uracil-DNA glycosylase (UDG), is a DNA repair enzyme that initiates the base excision repair (BER) pathway. UDG specifically recognizes and removes uracil residues from DNA, which can arise from cytosine deamination or dUTP misincorporation, preventing mutations and maintaining genomic integrity.
Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatogonia, Cytotrophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Monomer. Interacts with FAM72A. (Microbial infection) Interacts with HIV-1 Vpr.

Molecular function

Hydrolase

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