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WASF1
Anti-WASF1 Recombinant Antibody Products
- Mouse Anti-WASF1 Recombinant Antibody (clone mK91/36) (VS-0422-LC103)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG1
- Application: IB, IP, IHC
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- Rat Anti-WASF1 Recombinant Antibody (clone rtK91/36) (VS-0422-LC104)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IB, IP, IHC
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- Human Anti-WASF1 Recombinant Antibody (clone hK91/36) (VS-0422-LC105)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IB, IP, IHC
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- Rabbit Anti-WASF1 Recombinant Antibody (clone rK91/36) (VS-0422-LC106)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IB, IP, IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Excitatory neurons, Early spermatids, Oligodendrocytes)
Immune cell specificity
Group enriched (plasmacytoid DC, naive B-cell, memory B-cell)
Cell line specificity
Cell line enhanced (hTERT-HME1)
Interaction
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites.
Molecular function
Actin-binding
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