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ZIC1
Anti-ZIC1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Skeletal myocytes, Microglial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, MCF7, U-2197)
Interaction
Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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