Anti-38C13 Id Antibody-Cytokine Fusion Protein, scFv (chS5A8)-IL2 (CAT#: ACFP-SH027)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-38C13 Id scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the 38C13 Id as well as the biological activity of IL2. scFvS5A8-(IL2) had a short life and was eliminated 20-fold faster than chS5A8-(IL2), failed to confer protection suggesting the relevance of the Fc effector functions such as ADCC in anti-tumor activity against 38C13. This immunocytokine was a useful tool for the study of the mechanisms of protective immunity to B cell lymphoma and for the evaluation of different therapeutic approaches based on the stimulation or suppression of the immune response.
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Specifications
- Target
- 38C13 Id
- Molecule Class
- scFv-IL2
- Species Reactivity
- Mouse
- Expression Host
- CHO
- Clone
- chS5A8
- Related Disease
- This immunocytokine was a useful tool for the study of the mechanisms of protective immunity to B cell lymphoma and for the evaluation of different therapeutic approaches based on the stimulation or suppression of the immune response.
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- 38C13 Id; 38C13 idiotype
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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