Anti-CD22-MCC-DM1 ADC
CAT#: ADC-033LCT
This ADC product is composed of an anti-CD22 antibody conjuagated via a mcc linker to DM1 (anti-CD22-MCC-DM1). It has demonstrated a response in Acute Lymphoblastic Leukemia, non-Hodgkin's lymphoma, ALL, Haematological malignancies treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
Normal Tissue
Figure 2 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
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Specifications
- Antibody Overview
- Humanized monoclonal Antibody (Anti-CD22)
- Linker
- mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;
- Gene ID
- 933
- UniProt ID
- P20273
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COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-1716CL | Human Anti-CD22 Recombinant Antibody (TAB-1716CL) | Cyt, FuncS | Fully human antibody |
| TAB-1717CL | Human Anti-CD22 Recombinant Antibody (TAB-1717CL) | Cyt, FuncS | Fully human antibody |
| TAB-1718CL | Human Anti-CD22 Recombinant Antibody (TAB-1718CL) | Cyt, FuncS | Fully human antibody |
| TAB-1719CL | Human Anti-CD22 Recombinant Antibody (TAB-1719CL) | ELISA | Fully human antibody |
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| TAB-1724CL | Human Anti-CD22 Recombinant Antibody (TAB-1724CL) | Inhib | Chimeric (mouse/human) IgG1, κ |
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| TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
| TAB-001LC-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) | ELISA | Chimeric antibody (mouse/human) |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0196-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) | ELISA, FC, IP, RIA | Mouse IgG |
| HPAB-0197-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) | ELISA, FC, FuncS | Human IgG |
| HPAB-0198-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) | ELISA, WB, IF, FC, SPR | Mouse IgG |
| HPAB-0199-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) | ELISA, FC | Human IgG1 |
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| AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-176) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1899LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1899LY-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-1900LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1900LY-S(P)) | ELISA, Inhib | Mouse scFv |
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| HPAB-1902LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1902LY-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-2052-FY-S(P) | Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0034-YJ-F(E) | Mouse Anti-CD22 Recombinant Antibody (clone HB22-23); Fab Fragment | Block | Mouse Fab |
| HPAB-0709-FY-S(P) | Mouse Anti-CD22 Recombinant Antibody (clone AB008); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0370-FY-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0370-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-0371-FY-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0371-FY-F(E)) | Inhib | Humanized Fab |
| HPAB-2052-FY-F(E) | Human Anti-CD22 Recombinant Antibody (clone B28); Fab Fragment | FC | Human Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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