Afuco™ Anti-Human CD3E ADCC Recombinant Antibody (NI-0401), ADCC Enhanced

Name: Afuco™ Anti-Human CD3E ADCC Recombinant Antibody (NI-0401), ADCC Enhanced
SKU: AFC-118CL
Rating: 5 (1 reviews)

CAT#: AFC-118CL

Anti-CD3E ADCC Enhanced Antibody (NI-0401) is an ADCC enhanced antibody produced by our Afuco™ platform. NI-0401 is a monoclonal antibody (mAb) intended to alter auto-aggressive T-cell responses by targeting the T-cell receptor complex. A Phase I and Phase IIa clinical trial in Crohn's disease, and a Phase I / II open-label study in renal allograft transplantation have been completed.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg

Normal Tissue Figure 2 Lymph node

Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E

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Specifications

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Related Disease
Autoimmune Diseases

Product Property

Purity
>95% as judged by SDS-polyacrylamide gel electrophoresis

Storage
≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C

Target

Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Gene ID
916

UniProt ID
P07766

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-118CL.pdf

MSDS

MSDS - AFC-118CL.pdf

COA

Certificate of Analysis Lookup

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