Anti-CD3E immunotoxin (IgG)-RTA
CAT#: AGTO-L049R
This immunotoxin was achieved by conjugating/fusing the Anti-CD3E monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells which carry a CD3 epitope. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases.



Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- L kappa; IgG1-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases
Target
- Alternative Names
- CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3; T cell leukemias; lymphomas; graft-versus-host diseases; autoimmune diseases; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 916
- UniProt ID
- P07766
Customer Review
There are currently no Customer reviews or questions for AGTO-L049R. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "CD3E"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2a / G2b |
CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
FAMAB-0049-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody Fab Fragment (FAMAB-0049-YC-F(E)) | FC, FuncS | Hamster Fab |
FAMAB-0052-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); Fab Fragment | ELISA | Hamster Fab |
HPAB-0347-YJ-F(E) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); Fab Fragment | FC, WB, Inhib | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-714 | Anti-CD3E Recombinant Antibody (Visilizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG2 |
TAB-159 | Anti-Human CD3E Recombinant Antibody (TAB-159) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
TAB-H52 | Anti-Human CD3E Recombinant Antibody (TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
TAB-420CQ | Anti-Human CD3E Recombinant Antibody (Visilizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-245 | Anti-Human CD3 epsilon Recombinant Antibody (TAB-245) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-019 | Anti-Human CD3 Recombinant Antibody (TAB-019) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG2a - kappa |
PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
PABX-033-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study | |
AGTO-G010R | Anti-CD3E immunotoxin UCHT1 (scFv)-RTA | Cytotoxicity assay, Function study | |
AGTO-L049E | Anti-CD3E immunotoxin (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L049D | Anti-CD3E immunotoxin (IgG)-DT | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody scFv Fragment (FAMAB-0049-YC-S(P)) | FC, FuncS | Hamster scFv |
HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
HPAB-0347-YJ-S(P) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); scFv Fragment | FC, WB, Inhib | Rat scFv |
HPAB-0385-FY-S(P) | Human Anti-CD3E Recombinant Antibody; scFv Fragment (HPAB-0385-FY-S(P)) | Activ | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2278MZ | Mouse Anti-CD3E Recombinant Antibody (clone QT2) | IHC-P | Mouse IgG2a |
FN-264CQ | Rat Anti-CD3E Recombinant Antibody (clone KT3) | FC, IHC | Rat IgG2a |
FAMAB-1057CQ | Human Anti-CD3E Recombinant Antibody (clone PC3/188A) | WB, IHC | Human IgG1 |
VS3-XY298 | Mouse Anti-CD3E Recombinant Antibody (clone 4E2) | ELISA, WB, FC | Mouse IgG1 |
VS3-FY285 | Recombinant Mouse Anti-CD3E Antibody (clone 8D6-6C1-3B2) | IHC-P | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-159 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-159) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-245) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0724-XY17 | Mouse Anti-CD3E Agonistic Antibody (VS-0724-XY17) | FC, IP, ICC, Agonistic assays | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0724-YC1433 | AbPlus™ Anti-CD3E Magnetic Beads (VS-0724-YC1433) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY94 | Mouse Anti-NHP CD3E Recombinant Antibody (clone FN-18) | ELISA | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY46 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone 1F4) | FC | Mouse IgM, kappa |
VS-0225-XY47 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone SK7) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-FY110 | Human Anti-CD3E (clone NI-0401) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC355 | Recombinant Anti-CD3E Vesicular Antibody, EV Displayed (VS-0425-YC355) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY1171 | Anti-CD3E Immunohistochemistry Kit | IHC | |
VS-0525-XY1172 | Anti-Mouse CD3E Immunohistochemistry Kit | IHC |
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, WB, BLI, SPR
Application: WB, IHC, FC, Cyt, ELISA
Application: WB, ELISA, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: IB, FC, ELISA, FuncS
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.