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anti-CD3E immunotoxin UCHT1 (IgG)-RTA (AGTO-L049R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD3E monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells which carry a CD3 epitope. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
UCHT1
Molecule Class
L kappa; IgG1-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases
Target
Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain
Entrez Gene ID
916
UniProt ID
P07766

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Mouse Anti-CD3E Antibody scFv Fragment (CLB-T3/4.1)    ( FAMAB-0047CQ-S(P) )
Recombinant Anti-mouse CD3e Antibody.    ( CBMAB-600NL )
Anti-Human CD3E Therapeutic Antibody (NI-0401)    ( TAB-124CL )
Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2)    ( PABX-033-S (P) )
Anti-CD3 Antibody-Cytokine Fusion Protein, IgG (OKT3)-IL2    ( ACFP-SH128 )
Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11)    ( PABX-032-S (P) )
>> MORE
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