Recombinant Chimpanzee Anti-DENV-4 Antibody (mAb 5H2) (CAT#: PABL-448)
Recombinant Chimpanzee Antibody (mAb 5H2) is capable of binding to DENV-4 , expressed in Chinese Hamster Ovary cells (CHO). This antibody potently neutralizes DENV-4 by binding to domain I of E.
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ELISA
Figure 1 ELISA binding of DENV4-specific and cross-reactive monoclonal antibodies on rDENV4/3 panel.
ELISA binding curves of DENV3, DENV4, DENV4/3 M12, DENV4/3 M14 and DENV4/3 M16 by DENV4-specific mAbs 5H2.
Widman, D. G., Young, E., Nivarthi, U., Swanstrom, J. A., Royal, S. R., Yount, B. L., ... & De Silva, A. M. (2017). Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4. Scientific reports, 7(1), 1-10.
Neut
Figure 2 Neutralization of DENV4-specific and cross-reactive monoclonal antibodies on rDENV4/3 panel.
U937-DC-SIGN Neutralization assays with DENV4-specific mAbs 5H2.
Widman, D. G., Young, E., Nivarthi, U., Swanstrom, J. A., Royal, S. R., Yount, B. L., ... & De Silva, A. M. (2017). Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4. Scientific reports, 7(1), 1-10.
Neut
Figure 3 In vitro neutralization assay of IgG 5H2 ΔD against DENV-4 parental viruses and antigenic variants.
The multiplicity of infection was 0.1.
Lai, C. J., Goncalvez, A. P., Men, R., Wernly, C., Donau, O., Engle, R. E., & Purcell, R. H. (2007). Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody. Journal of virology, 81(23), 12766-12774.
Specifications
- Immunogen
- Dengue virus 4
- Host Species
- Chimpanzee
- Derivation
- Chimpanzee
- Type
- IgG
- Specificity
- Tested positive against native DENV-4
- Species Reactivity
- DENV
- Clone
- mAb 5H2
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Neutralization.
Target
- Alternative Names
- Dengue virus; DENV; Flaviviridae; dengue virus 4; DENV 4; Flaviviridae
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-445 | Recombinant Chimpanzee Anti-DENV-4 Antibody Fab Fragment (mAb 5H2) | WB, ELISA, FuncS | Fab |
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