Recombinant Anti-human NCT Intrabody [(D-Arg)9]
CAT#: IAB-B045(A)
Recombinant anti-NCT intrabody linked to (D-Arg)9 works within cells to suppressed the NCT activity, expressed in CHO cells. Nicastrin (NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the γ-secretase complex.
Specifications
- Immunogen
- human Nicastrin
- Host Species
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Western blot; Coimmunopricipation; Functional studies
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- NCT; Nicastrin; Anterior pharynx defective 2; APH2; ATAG1874; KIAA0253; NCSTN; NICA_HUMAN; RP11 517F10.1; RP11517F101
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "NCT"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B045(G) | Recombinant Anti-human NCT Intrabody [+36 GFP] | IF, ELISA, FuncS | scFv-(+36GFP) |
| IAB-B045(T) | Recombinant Anti-human NCT Intrabody [Tat] | FC, IF, FuncS | scFv-Tat |
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