Recombinant Anti-human NCT Intrabody [(D-Arg)9]

CAT#: IAB-B045(A)

Recombinant anti-NCT intrabody linked to (D-Arg)9 works within cells to suppressed the NCT activity, expressed in CHO cells. Nicastrin (NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the γ-secretase complex.

Specifications

  • Immunogen
  • human Nicastrin
  • Host Species
  • mouse
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Formats of immunological tests: Western blot; Coimmunopricipation; Functional studies

Product Property

  • Purity
  • >95%, by SDS-PAGE, under reducing conditions
  • Storage
  • ≤6 months at 4°C; ≥6 months at -20°C.

Target

  • Alternative Names
  • NCT; Nicastrin; Anterior pharynx defective 2; APH2; ATAG1874; KIAA0253; NCSTN; NICA_HUMAN; RP11 517F10.1; RP11517F101
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for IAB-B045(A). Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "NCT"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
IAB-B045(G) Recombinant Anti-human NCT Intrabody [+36 GFP] IF, ELISA, FuncS scFv-(+36GFP)
IAB-B045(T) Recombinant Anti-human NCT Intrabody [Tat] FC, IF, FuncS scFv-Tat
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare