Anti-NCT Intrabody [(D-Arg)9] (IAB-B045(A))
Recombinant anti-NCT intrabody linked to (D-Arg)9 works within cells to suppressed the NCT activity, expressed in CHO cells. Nicastrin (NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the γ-secretase complex.
Specifications
- Immunogen
- human Nicastrin
- Host
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Western blot; Coimmunopricipation; Functional studies
Target
- Alternative Names
- NCT; Nicastrin; Anterior pharynx defective 2; APH2; ATAG1874; KIAA0253; NCSTN; NICA_HUMAN
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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