Anti-NCT Intrabody [Tat] (IAB-B045(T))
Recombinant anti-NCT intrabody in fusion with HIV Tat works within cells to suppressed the NCT activity, expressed in CHO cells. Nicastrin (NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the γ-secretase complex.
Specifications
- Immunogen
- human Nicastrin
- Host
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Flow Cytometry; Immunofluorescence; Functional studies
Target
- Alternative Names
- NCT; Nicastrin; Anterior pharynx defective 2; APH2; ATAG1874; KIAA0253; NCSTN; NICA_HUMAN
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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