Recombinant Anti-EGFRvIII × Anti-CD133 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L002
Recombinant Anti-EGFRvIII× Anti-CD133 Bispecific Antibody (Tandem Diabody) has been generated by applying the Crossmab format to generate an IgGshaped entity that binds each ligand with one arm. This BsAb is capable of redirecting lysis of B lymphoma cells by preactivated PBMC from healthy donors. It was designed for the treatment of hodgkin's Lymphoma.
Specifications
- Target
- EGFRvIII & CD133
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- EGFRvIII
- Host Species 1
- Mouse
- Target 2
- CD133
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Lymphoma
Target
- Target 1
- EGFRvIII
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;
- Target 2
- CD133
- Gene ID
- 8842
- UniProt ID
- O43490
- Alternative Names
- PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen
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