PE-B*27:05/Human RP-L7a (RRHWGGNVL) MHC Tetramer (CAT#: MHC-LC4465)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human RP-L7a of peptide RRHWGGNVL covering 110-118 and B*27:05 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- B*27:05
- Class
- Class I
- MHC Species
- Human
- Antigen
- RP-L7a
- Antigen Species
- Human
- Peptide
- RRHWGGNVL
- Range
- 110-118
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
- Alternative Names
- RPL7A; ribosomal protein L7a; L7A; TRUP; SURF3
- Gene ID
- 6130
- UniProt ID
- Q9BY74
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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