A*02:01/Human Immunodeficiency virus 1 Pr55(Gag) (TLNAWVKVV) MHC Pentamer (CAT#: MHC-YC160)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• Human Immunodeficiency virus 1 Pr55(Gag)

• Antigen Species
• HIV1

• Peptide
• TLNAWVKVV

• Range
• 24 19-27

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry. Host restriction factors such as monkey TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating. On the other hand, interactions with PDZD8 or CYPA stabilize the capsid.

• Alternative Names
• HIV1gp2

• Gene ID
• 155030

• UniProt ID
• P04591

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