Mouse Anti-Anti-HMFG antibody Recombinant Antibody (clone 11D10) (CAT#: HPAB-0040-YJ)
This product is a recombinant mouse antibody that recognizes human anti-HMFG antibody. Mab 11d10 works as an anti-idiotype vaccine and triggers the immune system to recognize and attack targeted cancer cells. Mab 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. It can be used in the treatment of Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Breast Cancer, Colorectal Cancer.
Specific Inquiry
FuncS
Figure 1 Anti-Id specificities of 11D10 (IgG 1 , IC).
Binding of ¹²⁵I-labeled 11D10 ( - 25, 000 cpm) to various mouse monoclonal proteins and anti-HMFG (breast TAA) antibodies was determined using a direct RIA.The isotypes of the monoclonal proteins are BrE-1 (lgG2b, IC), 1E3 (IgG 1 , IC), 4DC6 (lgG 1, X), BrE-3 (IgG 1 , IC) Hy-Clone IgG2b, lC; Hy-Clone IgG3, 1C; Hy-Clone IgA, IC; and MOPC l04E (lgM, X), RWP1-1 (lgG2b, IC). The results are presented as mean cpm (n = 3). The S.D. of the data was less than 10% for each assay.
Bhattacharya-Chatterjee, M., Mrozek, E., Mukerjee, S., Ceriani, R. L., Kohler, H., & Foon, K. A. (1994). Anti-idiotype antibodies as potential therapeutic agents for human breast cancer. In Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment (pp. 139-148). Springer, Boston, MA.
Vaccines
Figure 2 Immune flow cytometry analysis of MCF-7 cells with monkey Ab3 sera.
A, tumor cells were reacted with preimmune sara and Ab3 sera (1:100 dilution) from monkeys immunized with 11D10. The reaction was developed with goat anti-human F(ab')2 IgG-FITC-labeled antibody. In B, MOLT-4 cells that do not express HMFG were reacted with preimmune and immune monkey Ab3 sara raised against 11D10.
Chakraborty, M., Mukerjee, S., Foon, K. A., Köhler, H., Ceriani, R. L., & Bhattacharya-Chatterjee, M. (1995). Induction of human breast cancer-specific antibody responses in cynomolgus monkeys by a murine monoclonal anti-idiotype antibody. Cancer research, 55(7), 1525-1530.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human
- Species Reactivity
- Human, Mouse, Rabbit, Monkey
- Clone
- 11D10
- Applications
- FuncS, Inhib, ELISA, RIA, Vaccines
- Related Disease
- Tumor, Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody 11D10 has been reported in applications of Functional Assay, Inhibition, Enzyme-linked Immunosorbent Assay, Radioimmunoassay, Vaccines. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Anti-HMFG Antibody; Anti-HMFG mAb; 11D10; TriAb
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YJ-S(P) | Mouse Anti-Anti-HMFG antibody Recombinant Antibody (clone 11D10); scFv Fragment | ELISA, RIA, Inhib, Vaccine | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YJ-F(E) | Mouse Anti-Anti-HMFG antibody Recombinant Antibody (clone 11D10); Fab Fragment | ELISA, RIA, Inhib, Vaccine | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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