Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Liposome (VS-1024-FY142)
CAT#: VS-1024-FY142
Liposomes conjugated with anti-AOC3 antibodies have been used as targeted drug delivery systems in colorectal cancer to enhance the specificity and efficiency of treatment. Studies indicate that this conjugation helps concentrate drugs at the tumor site, reducing damage to normal cells. This approach has demonstrated stronger anti-tumor effects and significantly reduced side effects. Such liposomes provide new prospects for targeted therapy in colorectal cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/if_selected.jpg
Normal Tissue
Figure 2 Lung
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_1_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_7_3.jpg
Normal Tissue
Figure 4 Soft tissue
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25797/57908_B_2_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131471-AOC3
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- W24V142
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically engineered to target the enzyme AOC3, also known as amino oxidase copper containing 3. By harnessing advanced biotechnological techniques, this antibody has been designed to bind with high specificity and affinity to AOC3, which plays a crucial role in various physiological processes and has implications in several diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- AOC3
- Introduction
- This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
- Alternative Names
- AOC3; amine oxidase, copper containing 3; HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; amine oxidase, copper containing 3 (vascular adhesion protein
- Full Name
- Amine Oxidase, Copper Containing 3
- Gene ID
- 8639
- UniProt ID
- Q16853
- Sequence Similarities
- Belongs to the copper/topaquinone oxidase family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. ( Q16853-AOC3_HUMAN )
N- and O-glycosylated. ( Q16853-AOC3_HUMAN )
Glycosylation at Asn592, Asn618, Asn666, Asn137, Thr212, Asn232, and Asn294 ( NX_Q16853 [NX_Q16853-1] )
Modification sites at PhosphoSitePlus ( Q16853 )
Glycosylation from GlyConnect AOC3_HUMAN (1502)
Glycosylation from GlyGen (Q16853) 10 sites, 43 N-linked glycans (3 sites), 1 O-linked glycan
- Protein Refseq
- XP_011523721.1; XP_011523722.1; XP_024306783.1; XP_047292938.1; XP_047292939.1
- Function
- Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, 24304424, 9653080).
Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, 9653080).
Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076).
At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.
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Datasheet
MSDS
COA
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|---|---|---|---|
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| HPAB-1628LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10) | ELISA | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-137 | Anti-Human AOC3 Recombinant Antibody (TAB-137) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045CL | Human Anti-AOC3 Recombinant Antibody (TAB-045CL) | ELISA | Human IgG |
| TAB-455CQ | Anti-Human AOC3 Recombinant Antibody (Timolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-098CN | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG1, κ |
| NS-099CN | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG |
| NS-098CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-099CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); scfv Fragment | ELISA | Mouse scfv |
| HPAB-0966-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0966-FY-F(E)) | IF | Human Fab |
| HPAB-0967-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0967-FY-F(E)) | IF | Human Fab |
| HPAB-0968-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0968-FY-F(E)) | IF | Human Fab |
| HPAB-0969-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0969-FY-F(E)) | IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1628LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1629LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0966-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0966-FY-S(P)) | IF | Human scFv |
| HPAB-0967-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0967-FY-S(P)) | IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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