Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Liposome (VS-1024-FY142) (CAT#: VS-1024-FY142)

• Potential Clinical Applications
• Colorectal cancer

• Clone
• W24V142

• Antibody Type
• IgG1, kappa

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that was specifically engineered to target the enzyme AOC3, also known as amino oxidase copper containing 3. By harnessing advanced biotechnological techniques, this antibody has been designed to bind with high specificity and affinity to AOC3, which plays a crucial role in various physiological processes and has implications in several diseases.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• AOC3

• Introduction
• This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.

• Alternative Names
• AOC3; amine oxidase, copper containing 3; HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; amine oxidase, copper containing 3 (vascular adhesion protein

• Full Name
• Amine Oxidase, Copper Containing 3

• Gene ID
• 8639

• UniProt ID
• Q16853

• Sequence Similarities
• Belongs to the copper/topaquinone oxidase family.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein

• Post Translation Modifications
• Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. ( Q16853-AOC3_HUMAN )
  N- and O-glycosylated. ( Q16853-AOC3_HUMAN )
  Glycosylation at Asn592, Asn618, Asn666, Asn137, Thr212, Asn232, and Asn294 ( NX_Q16853 [NX_Q16853-1] )
  Modification sites at PhosphoSitePlus ( Q16853 )
  Glycosylation from GlyConnect AOC3_HUMAN (1502)
  Glycosylation from GlyGen (Q16853) 10 sites, 43 N-linked glycans (3 sites), 1 O-linked glycan

• Protein Refseq
• XP_011523721.1; XP_011523722.1; XP_024306783.1; XP_047292938.1; XP_047292939.1

• Function
• Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, 24304424, 9653080).
  Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, 9653080).
  Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076).
  At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.

Select a product category from the dropdown menu below to view related products.