Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Liposome (VS-1024-FY142) (CAT#: VS-1024-FY142)

Liposomes conjugated with anti-AOC3 antibodies have been used as targeted drug delivery systems in colorectal cancer to enhance the specificity and efficiency of treatment. Studies indicate that this conjugation helps concentrate drugs at the tumor site, reducing damage to normal cells. This approach has demonstrated stronger anti-tumor effects and significantly reduced side effects. Such liposomes provide new prospects for targeted therapy in colorectal cancer.

Sub Cat Product Name Liposome Name Datasheet  
VS-1124-FY2398 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled PEGylated Liposome (VS-1124-FY2398) PEGylated liposome
VS-1124-FY2399 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Triptolide-loaded Liposome (VS-1124-FY2399) Triptolide-loaded liposome
VS-1124-FY2400 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Gd-SLs Liposome (VS-1124-FY2400) Gd-SLs liposome
VS-1124-FY2401 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Phospholipid Liposome (VS-1124-FY2401) Phospholipid liposome
VS-1124-FY2402 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Cationic Liposome (VS-1124-FY2402) Cationic liposome
VS-1124-FY2403 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Adriamycin-encapsulated Liposome (VS-1124-FY2403) Adriamycin-encapsulated liposome
VS-1124-FY2404 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Magnetofluorescent Liposome (VS-1124-FY2404) Magnetofluorescent liposome
VS-1124-FY2405 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled pH-sensitive Liposome (VS-1124-FY2405) pH-sensitive liposome
VS-1124-FY2406 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Phototoxic Liposome (VS-1124-FY2406) Phototoxic liposome
VS-1124-FY2407 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Targeted Liposome (VS-1124-FY2407) Targeted Liposome
VS-1124-FY2408 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Apt1-Liposome (VS-1124-FY2408) Apt1-liposome
VS-1124-FY2409 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Thermosensitive Liposome (VS-1124-FY2409) Thermosensitive liposome
VS-1124-FY2410 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Clodronate Liposome (VS-1124-FY2410) Clodronate liposome
VS-1124-FY2411 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Galcer Liposome (VS-1124-FY2411) Galcer liposome
VS-1124-FY2412 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled HBsAg-loaded Liposome (VS-1124-FY2412) HBsAg-loaded liposome
VS-1124-FY2413 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled Phospholipid Liposome and Cationic Liposome (VS-1124-FY2413) Phospholipid liposome and Cationic liposome
VS-1124-FY2414 Anti-AOC3 (clone W24V142) Recombinant Antibody Coupled ISMN Liposome (VS-1124-FY2414) ISMN liposome
More Infomation
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Potential Clinical Applications
  • Colorectal cancer

Product Composition

  • Clone
  • W24V142
  • Antibody Type
  • IgG1, kappa
  • Antibody Host
  • Human
  • Antibody Reactivity
  • Human
  • Antibody Description
  • This is a recombinant human monoclonal antibody that was specifically engineered to target the enzyme AOC3, also known as amino oxidase copper containing 3. By harnessing advanced biotechnological techniques, this antibody has been designed to bind with high specificity and affinity to AOC3, which plays a crucial role in various physiological processes and has implications in several diseases.

Product Property

  • Storage
  • See in the COA
  • Storage Shelf Time
  • See in the COA

Target Information

  • Target
  • AOC3
  • Introduction
  • This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • AOC3; amine oxidase, copper containing 3; HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; amine oxidase, copper containing 3 (vascular adhesion protein
  • Full Name
  • Amine Oxidase, Copper Containing 3
  • Sequence Similarities
  • Belongs to the copper/topaquinone oxidase family.
  • Cellular Localization
  • Cell membrane; Single-pass type II membrane protein
  • Post Translation Modifications
  • Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. ( Q16853-AOC3_HUMAN )
    N- and O-glycosylated. ( Q16853-AOC3_HUMAN )
    Glycosylation at Asn592, Asn618, Asn666, Asn137, Thr212, Asn232, and Asn294 ( NX_Q16853 [NX_Q16853-1] )
    Modification sites at PhosphoSitePlus ( Q16853 )
    Glycosylation from GlyConnect AOC3_HUMAN (1502)
    Glycosylation from GlyGen (Q16853) 10 sites, 43 N-linked glycans (3 sites), 1 O-linked glycan
  • Function
  • Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, 24304424, 9653080).
    Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, 9653080).
    Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076).
    At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "AOC3"

Select a product category from the dropdown menu below to view related products.
Please select product type
Chimeric Antibody Products IgM Antibody Products Human Antibody Products Rabbit Monoclonal Antibody Products Neuroscience Antibody Products ScFv Antibody Products IgG Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads
CAT Product Name Application Type
TAB-261 Anti-Human AOC3 Recombinant Antibody (Vapaliximab) WB, FC, IP, ELISA, Neut, FuncS, IF IgG2

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for VS-1024-FY142. Click the button above to contact us or submit your feedback about this product.

Popular products with customers


For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Go to compare

    Go to compare