Mouse Anti-CACNA1D Recombinant Antibody (clone S48) (CAT#: VS-0625-FY17)
This Mouse IgG2a kappa monoclonal antibody, clone S48, broadly targets CACNA1D in Human, Mouse, and Rat. Its immunogen is a recombinant Rat CACNA1D fusion protein, with an epitope mapping to amino acids 859-875. With an approximate antigen size of 45 kDa, this antibody is applicable in ICC/IF (1:100), IHC (1:1000), and WB (1:1000), offering versatile detection for CACNA1D.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/1525_G2_6_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/1525_G2_6_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_B_9_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_B_9_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_4.jpg
Figure 5 Pancreas
(Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_3_3.jpg
(Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_3_3.jpg
Figure 6 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_4_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_4_6.jpg
Figure 8 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_7_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157388-CACNA1D
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157388-CACNA1D
Specifications
- Immunogen
- A recombinant rat Cav1.3 fusion protein, comprising amino acids 859-875.
- Host Species
- Mouse
- Type
- Mouse IgG2a, kappa
- Specificity
- Detects a protein of approximately 250 kDa. No cross-reactivity was observed with Cav1.2.
- Species Reactivity
- Human, Mouse, Rat
- Clone
- S48
- Applications
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Related Disease
- Primary Aldosteronism, Autism Spectrum Disorder (with specific variants).
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4, 50% glycerol
- Preservative
- 0.09% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunocytochemistry/Immunofluorescence: 1:100
Immunohistochemistry: 1:1000
Western Blot: 1:1000
Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Calcium Voltage-Gated Channel Subunit Alpha1 D; Calcium Channel, Voltage-Dependent, L Type, Alpha 1D Subunit; CACNL1A2; CCHL1A2; CACH3; CACN4; Calcium Channel, Neuroendocrine/Brain-Type, Alpha 1 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D; Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 2
- Gene ID
- 776
- UniProt ID
- Q01668
- Long Name
- Calcium Voltage-Gated Channel Subunit Alpha1 D
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1589 | PE-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer | FCM | |
| MHC-LC1590 | APC-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer | FCM | |
| MHC-LC1591 | BV421-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer | FCM |
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