Human Anti-CD3E Recombinant Antibody (clone C3E-1)
CAT#: VS-0724-XY72
This antibody is a recombinant human antibody. It specifically reacts with human CD3E and it also has cross-reactivity against cynomolgus monkey. The affinity of this antibody against human CD3E is 0.117 nM. It has been detected using ELISA and Surface plasmon resonance.



Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- CD3E
- Species Reactivity
- Human, Monkey
- Clone
- C3E-1
- Applications
- ELISA, SPR, FC
- Related Disease
- Immunodeficiency 18
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- SPR: Five different concentrations of the antibody C3E-1 were injected into CD3E immobilized on a sensor chip.
Target
- Alternative Names
- T3E; TCRE; IMD18; CD3epsilon
- Gene ID
- 916
- UniProt ID
- P07766
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Ubiquitination at Lys104 and Lys177.
- Protein Refseq
- NP_000724.1
- Function
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.
All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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