PTM™ Rabbit Anti-CREB1 (pSer133) Recombinant Antibody (VS13-YC245) (CAT#: VS13-YC245)

• Immunogen
• Synthetic phosphopeptide of human Creb (pSer133).

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• The phosphorylated CREB1 (Ser133) of human and mouse.

• Species Reactivity
• Human, Mouse

• Applications
• WB, ICC, IF, IHC-P, IP, FC

• Conjugate
• NONE

• Related Disease
• Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000
  Immunocytochemistry (ICC): 1/50-1/100
  Immunohistochemistry-paraffin (IHC-P): 1/50-1/400
  Flow cytometry (FC): 1/50-1/100

• Alternative Names
• CAMP Responsive Element Binding Protein 1; CREB-1; Cyclic Adenosine 3, 5-Monophosphate Response Element-Binding Protein CREB; Cyclic AMP-Responsive Element-Binding Protein 1; CAMP-Responsive Element-Binding Protein 1; CAMP-Response Element-Binding Protein-1; Active Transcription Factor CREB; Transactivator Protein; CREB;

• Gene ID
• 1385

• UniProt ID
• P16220

• Long Name
• CAMP Responsive Element Binding Protein 1

• Sequence Similarities
• Belongs to the bZIP family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Phosphorylated

• Protein Refseq
• NP_004370.1; NP_604391.1

• Function
• Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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