Human Anti-HIV-1 gp120 Recombinant Antibody (clone 49G2) (CAT#: MRO-3244CQ)
Recombinant human antibody to gp120. The antibody can bind to several complementary regions of gp120 and synergistically neutralized a wide range of HIV subtypes.
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Inhib
Figure 1 Effect of C34 resistance-conferring mutations on the sensitivities to anti-CD4bs MAb and sCD4.
Three mutations that together confer C34 resistance, I37K, N126K, and L204I, were examined for their effect on the neutralization sensitivity to anti-CD4bs Mab 49G2 using single mutants.
Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Valdez, K. P. R., Tanaka, K., ... & Matsuoka, M. (2016). Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors. Retrovirology, 13(1), 70.
FC
Figure 2 Binding of antibodies to untriggered envelope trimers.
The effect of fusion inhibitor resistance-conferring mutations on the binding of anti-CD4bs Mab 49G2 was determined by performing flow cytometry on 293T cells expressing mutant envelopes.
Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Valdez, K. P. R., Tanaka, K., ... & Matsuoka, M. (2016). Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors. Retrovirology, 13(1), 70.
Specifications
- Host Species
- Human
- Type
- Human IgG1, λ
- Specificity
- Recognizes HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- 49G2
- Applications
- Inhib, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry and Inhibition.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-028LC-VHH) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-029LC-VHH) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-030LC-VHH) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-031LC-VHH) | ELISA | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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