Recombinant human antibody to gp120. 5145A is the CD4bs-targeting, neutralizing anti-gp120 mAb exhibiting ADCC activity and having a discontinuous epitope.
Figure 1 Effects of reduction and deglycosylation on stability of epitopes in the V2 and other domains.
Recombinant BaL gp120 was captured on wells of a 96-well ELISA plate either untreated (open squares) or after deglycosylation with peptide N-glycosidase F (PNGase
F; closed diamonds) or reduction by DTT (closed triangles). The reactivity of the indicated MAbs to control or treated rgp120 was titrated for 1 h at 37°C and bound antibody detected with alkaline phosphatase-conjugated anti-IgG, followed by incubation with alkaline phosphatase substrate. OD405, optical density at 405 nm.
Pinter, A., Honnen, W. J., D'Agostino, P., Gorny, M. K., Zolla-Pazner, S., & Kayman, S. C. (2005). The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates. Journal of virology, 79(11), 6909-6917.
Figure 2 Effects of mutations in the JR-FL V2 domain on neutralization by CD4-binding domain (5145A).
Neutralization assays were performed with env deleted, luc-expressing NL4-3 provirus pseudotypes with either the parental JR-FL Env (closed triangles) or the JR(GKV) variant expressing the C108g epitope in the JR-FL background (open triangles).
Pinter, A., Honnen, W. J., D'Agostino, P., Gorny, M. K., Zolla-Pazner, S., & Kayman, S. C. (2005). The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates. Journal of virology, 79(11), 6909-6917.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); Fab Fragment | Neut, FuncS | Human Fab |
PFBL-538 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3B3); Fab Fragment | Neut | Human Fab |
PFBL-540 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 537-10D); Fab Fragment | ELISA | Human Fab |
PFBL-541 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b13); Fab Fragment | Neut | Human Fab |
PFBL-543 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247); Fab Fragment | Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3140CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH57); scFv Fragment | ELISA | Human scFv |
MRO-3141CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH77); scFv Fragment | ELISA | Human scFv |
MRO-3142CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH81); scFv Fragment | ELISA | Human scFv |
MRO-3143CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH89); scFv Fragment | ELISA | Human scFv |
MRO-3144CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH92); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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