Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 11A8 (426 11A8)) (CAT#: MRO-3867CQ)
Recombinant mouse antibody to gp160(426-441). MAb 11A8 binds to gp120 of clade B. 11A8 epitope is cryptic in gp120.
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ELISA
Figure 1 Binding of anti MCPs sera to gp120 is blocked by preincubation with the specific MCP immunogen.
Binding of antibodies to gp120 was determined by ELISA.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
Inhib
Figure 2 MAbs 11A8 and 2D3 compete for binding to gp120.
Concentration of biotinylated 2D3 in the assay was 1.2 nM, concentrations of competing, unconjugated MAbs 2D3 and 11A8 were as indicated.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
FC
Figure 3 MAb elicited by 426 MCP (11A8) recognizes HIV-1 on the surface of infected cells.
Antibody binding was detected using PE conjugated secondary antibody and measured by flow cytometry. Flow histogram plots are displayed.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Recognizes HIV-1 gp160(426-441)
- Species Reactivity
- HIV-1
- Clone
- 11A8 (426 11A8)
- Applications
- ELISA, FC, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp160 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody; Fab Fragment (PFBL-177) | WB, ELISA, Neut, FuncS | Human Fab |
| PFBL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (PFBL-178) | WB, ELISA, FuncS | Human Fab |
| PFBL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
| PFBL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01); Fab Fragment | FC, Neut, FuncS | Human Fab |
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