Mouse Anti-HIV CD4bs Recombinant Antibody (clone N-p4a9) (CAT#: FAMAB-0188WJ)
This product is an anti-HIV-1 neutralizing antibody (clone N-p4a9) that targets the CD4-binding site of Env. N-p4a9 was generated from unimmunized animals. Neither 426c WT Core nor HxB2 WT Core proteins could be immunoprecipitated by the N-p4a9.
Specific Inquiry
Co-IP
Figure 1 Vaccine Elicited Antibodies Bind in to Env Core with Glycans at N276.
Following co-immunoprecipitation, 426c WT Core (left) and HxB2 WT Core (right) were washed and eluted from the beads.
Parks, K. R., MacCamy, A. J., Trichka, J., Gray, M., Weidle, C., Borst, A. J., Khechaduri, A., Takushi, B., Agrawal, P., Guenaga, J., Wyatt, R. T., Coler, R., Seaman, M., LaBranche, C., Montefiori, D. C., Veesler, D., Pancera, M., McGuire, A., & Stamatatos, L. (2019). Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization. Cell reports, 29(10), 3060–3072.e7.
Specifications
- Immunogen
- 426c Core Env
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG
- Specificity
- CD4-binding site of Env
- Species Reactivity
- HIV-1
- Clone
- N-p4a9
- Applications
- ELISA, WB, Neut
- Related Disease
- HIV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Human immunodeficiency virus; HIV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0178WJ | Human Anti-HIV CD4bs Recombinant Antibody (clone N49P6) | ELISA, WB, Neut | Human IgG |
| FAMAB-0179WJ | Human Anti-HIV CD4bs Recombinant Antibody (clone N49P11) | ELISA, WB, Neut | Human IgG |
| FAMAB-0180WJ | Human Anti-HIV CD4bs Recombinant Antibody (clone N49P9) | ELISA, WB, Neut | Human IgG |
| FAMAB-0181WJ | Human Anti-HIV CD4bs Recombinant Antibody (clone N60P1.1) | ELISA, WB, Neut | Human IgG |
| FAMAB-0182WJ | Mouse Anti-HIV CD4bs Recombinant Antibody (clone P-p1e7) | ELISA, WB, Neut | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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