Recombinant Arabian camel Anti-IL-6-gp80 complex Single Domain Antibody (PABC-587) (CAT#: PABC-587)
This product is a recombinant Arabian camel antibody that can recognize IL-6-gp80 complex. VHH6 is able to recognize and bind only to the IL-6–gp80 complex. VHH6 specifically recognizes an epitope that spans the junction between IL-6 and gp80, locking them together in a stable functional unit.
Specific Inquiry
SPR
Figure 1 A qualitative SPR experiment was performed immobilizing IL-6 on a CM5 chip and injecting gp80.
The blue curve represents a typical sensorgram of gp80 binding to IL-6; t red curve is the sensorgram resulting from gp80 binding to IL-6 with VHH6 injected at the beginning of the dissociation phase for gp80, showing an inhibition of gp80 dissociation curve (y-axis: RU; x-axis: time (s)).
Adams, R., Burnley, R. J., Valenzano, C. R., Qureshi, O., Doyle, C., Lumb, S., ... & Meier, C. (2017). Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein: protein interaction and modulates its downstream signaling. Scientific reports, 7, 37716.
Specifications
- Immunogen
- HyperIL-6, a fusion protein of gp80 joined to IL-6 with a flexible peptide linker
- Host Species
- Arabian camel
- Type
- Arabian camel VHH
- Specificity
- Human IL-6-gp80 complex
- Species Reactivity
- Human
- Clone
- PABC-587
- Applications
- ELISA, SPR
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Surface Plasmon Resonance. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- IL-6-gp80 complex
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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