Anti-NFKB1 (clone W24V21) Recombinant Antibody Coupled Liposome (VS-1024-FY22) (CAT#: VS-1024-FY22)

• Potential Clinical Applications
• Potentially kill T cell lines (e.g. CCRFCEM)

• Clone
• W24V21

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant antibody that was derived from mouse origins, specifically engineered to recognize and bind to the NF-kB protein, a critical regulator of various cellular processes, including inflammation, immunity, and cell survival.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• NFKB1

• Introduction
• This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

• Alternative Names
• Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; DNA-Binding Factor KBF1; EBP-1; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P105 Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B; NF-KappaB

• Full Name
• Nuclear Factor Kappa B Subunit 1

• Gene ID
• 4790

• UniProt ID
• P19838

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Generation of the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) transcription factor takes place both cotranslationally and post-translationally via non-mutually exclusive mechanisms (PubMed:10970863, 25860612, 8628291, 9529257).
  A cotranslational processing allows the production of both p50 and p105 (Nuclear factor NF-kappa-B p105 subunit) from a single NFKB1 mRNA.

• Protein Refseq
• XP_024309836.1; XP_024309837.1; XP_047271698.1; XP_047271699.1; XP_047271700.1

• Function
• NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.
  NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one.
  The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.

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