Anti-NFKB1 (clone W24V21) Recombinant Antibody Coupled Liposome (VS-1024-FY22)
CAT#: VS-1024-FY22
Antibody-conjugated liposomes targeting NF-κB may enhance antitumor effects against tumor cells by improving cell-specific binding and internalization, potentially leading to the destruction of T cell lines. This approach may be applicable for the treatment targeting tumor cells, but specific mechanisms and effects require further research support.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27305/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4031/11361_A_9_8.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4031/11361_A_9_3.jpg
RNA Expression
Figure 4 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109320-NFKB1
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More Infomation
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- W24V21
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody that was derived from mouse origins, specifically engineered to recognize and bind to the NF-kB protein, a critical regulator of various cellular processes, including inflammation, immunity, and cell survival.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NFKB1
- Introduction
- This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
- Alternative Names
- Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; DNA-Binding Factor KBF1; EBP-1; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P105 Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B; NF-KappaB
- Full Name
- Nuclear Factor Kappa B Subunit 1
- Gene ID
- 4790
- UniProt ID
- P19838
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Generation of the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) transcription factor takes place both cotranslationally and post-translationally via non-mutually exclusive mechanisms (PubMed:10970863, 25860612, 8628291, 9529257).
A cotranslational processing allows the production of both p50 and p105 (Nuclear factor NF-kappa-B p105 subunit) from a single NFKB1 mRNA.
- Protein Refseq
- XP_024309836.1; XP_024309837.1; XP_047271698.1; XP_047271699.1; XP_047271700.1
- Function
- NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.
NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one.
The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.
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Related Signaling Pathways
BCR Signaling Pathway
cAMP Signaling Pathway
NLR Signaling Pathway
TCR Signaling Pathway
TLR Signaling Pathway
TNF Signaling Pathway
Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "NFKB1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1566z | Mouse Anti-NFKB1 Recombinant Antibody (clone 31H12) | WB, IF, IHC | Mouse IgG1 |
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| VS3-CJ754 | Rabbit Anti-NFKB1 Recombinant Antibody (VS3-CJ754) | WB, IHC | Rabbit IgG |
| VS3-FY2819 | Mouse Anti-NFKB1 Recombinant Antibody (VS3-FY2819) | WB | Mouse IgG |
| VS7-0425-WR473 | Mouse Anti-NFKB1 Monoclonal Antibody (clone 5D10) | WB, IHC, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0391MZ | Chicken Anti-NFKB1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2433 | Hi-Affi™ Recombinant Rabbit Anti-NFKB1 Monoclonal Antibody (DS2433AB) | WB, IHC-P, ICC, FC | IgG |
| MOR-4511 | Hi-Affi™ Recombinant Rabbit Anti-NFKB1 Monoclonal Antibody (TH19DS) | WB, FC | IgG |
| MOR-0096-FY | Rabbit Anti-NFKB1 Recombinant Antibody (clone AFY0067) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1090-CN | Recombinant Mouse Anti-NFKB1 Monoclonal Antibody (A2-7) | WB, IF, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4817 | Anti-NFKB1 Immunohistochemistry Kit | IHC |
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