Recombinant Human Anti-NPNA Antibody (PfNPNA-1) (CAT#: FAMAB-0225-CN)
The fully human monoclonal antibody PfNPNA-1 against (NPNA)3 specifically labels Plasmodium falciparum in an IFA. PfNPNA-1 is a promising candidate for evaluation for the prevention of malaria.
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IF
Figure 1 Indirect immunofluorescence assay (IFA) on Plasmo-dium falciparum sporozoites.
Anti-sporozoite activity of the PfNPNA-1 VH/κ moleculewas clearly evident in an immunofluorescence assay (IFA) with P. falciparum sporozoites.
Chappel, J. A., Rogers, W. O., Hoffman, S. L., & Kang, A. S. (2004). Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor. Malaria journal, 3(1), 28.
ELISA
Figure 2 Competition ELISA was carried out to approximate the affinity of binding.
Binding affinity ofthe monovalent PfNPNA-1 for (NPNA)3 comparedfavourably with values previously reported for a panel ofconventional murine monoclonal antibodies directedagainst the repeat epitope, which also have affinitiesin the µM range.
Chappel, J. A., Rogers, W. O., Hoffman, S. L., & Kang, A. S. (2004). Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor. Malaria journal, 3(1), 28.
Specifications
- Host Species
- Human
- Type
- Human IgG4
- Specificity
- Plasmodium falciparum NPNA
- Species Reactivity
- Plasmodium falciparum
- Clone
- PfNPNA-1
- Applications
- ELISA, IF
- Related Disease
- Malaria
Product Property
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Immunofluorescence.
Target
- Alternative Names
- NPNA
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0225-CN-S(P) | Recombinant Human Anti-NPNA Antibody scFv Fragment (PfNPNA-1) | ELISA, IF | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0225-CN-F(E) | Recombinant Human Anti-NPNA Antibody Fab Fragment (PfNPNA-1) | ELISA, IF | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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