Rabbit Anti-PRKCG Recombinant Antibody (clone R06-8C6) (CAT#: VS3-FY1835)

• Immunogen
• Recombinant human PKC protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat PRKCG

• Species Reactivity
• Human, Rat

• Clone
• R06-8C6

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 78 kDa, while the observed molecular weight stands at 78 kDa.

• Related Disease
• Spinocerebellar Ataxia 14 and Hereditary Ataxia

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• PKCG; SCA14

• Gene ID
• 5582

• UniProt ID
• P05129

• Sequence Similarities
• Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

• Cellular Localization
• Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

• Post Translation Modifications
• Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4. (P05129-KPCG_HUMAN)
  Ubiquitinated. (P05129-KPCG_HUMAN)
  Modification sites at PhosphoSitePlus (P05129)
  Modification sites at neXtProt (NX_P05129)

• Protein Refseq
• XP_047295048.1; XP_054177413.1; NP_001303258.1; NP_002730.1

• Function
• Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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