Rabbit Anti-SEC62 Recombinant Antibody (clone R33-1I-5) (CAT#: VS3-XY3497)
This antibody is a recombinant rabbit antibody targeting the SEC62 (SEC62 homolog, preprotein translocation factor), which mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). The antibody specifically reacts with human, mouse and rat SEC62. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SEC62
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R33-1I-5
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Polycystic Liver Disease; Hereditary Sensory; Autonomic Neuropathy Type 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/100-1/200
IF: 1/50-1/200
Target
- Alternative Names
- HTP1; TP-1; Dtrp1; TLOC1
- Gene ID
- 7095
- UniProt ID
- Q99442
- Long Name
- SEC62 homolog, preprotein translocation factor
- Cellular Localization
- Endoplasmic reticulum membrane
- Post Translation Modifications
- Ubiquitination at Lys19, Lys51, and Lys60 (NX_Q99442 [NX_Q99442-1])
Modification sites at PhosphoSitePlus (Q99442)
Glycosylation from GlyGen (Q99442) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047304775.1; XP_011511416.1
- Function
- Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER).
Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides.
Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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