Anti-TNF (clone CB0006) Recombinant Antibody Coupled Liposome (VS-1024-FY14) (CAT#: VS-1024-FY14)

• Potential Clinical Applications
• Early detection of atherosclerotic plaques, Ischemic myocardium in vivo

• Clone
• CB0006

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse monoclonal antibody that has been specifically engineered to target tumor necrosis factor-alpha (TNF-α). TNF-α is a critical cytokine involved in systemic inflammation and plays a key role in various inflammatory diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• TNF

• Introduction
• This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

• Alternative Names
• Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin; TNF-Alpha; TNFSF2; TNF-A; TNFA; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F

• Full Name
• Tumor Necrosis Factor

• Gene ID
• 7124

• UniProt ID
• P01375

• Sequence Similarities
• Belongs to the tumor necrosis factor family.

• Cellular Localization
• Cell membrane, Membrane, Secreted

• Post Translation Modifications
• The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
  The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
  O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
  Tumor necrosis factor, soluble form: The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion.

• Protein Refseq
• NP_000585.2

• Function
• Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208).
  Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).
  Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819).
  The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

• VS-1024-FY279
• Anti-TNF (clone STI002) Recombinant Antibody Coupled Liposome (VS-1024-FY279)

• HPAB-0017-YJ
• Mouse Anti-TNF Recombinant Antibody (clone CB0006)

• HPAB-0017-YJ-S(P)
• Mouse Anti-TNF Recombinant Antibody (clone CB0006); scFv Fragment

• HPAB-0017-YJ-F(E)
• Mouse Anti-TNF Recombinant Antibody (clone CB0006); Fab Fragment

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