Anti-TNF (clone CB0006) Recombinant Antibody Coupled Liposome (VS-1024-FY14)
CAT#: VS-1024-FY14
Anti-TNF-α conjugated liposomes have shown potential in the early detection of atherosclerotic plaques and can be used to improve the diagnosis of atherosclerosis. This approach leverages the latest advancements in nanomaterials and is expected to provide better detection methods in non-invasive imaging techniques.
The study on the application of anti-TNF-α antibody-loaded liposomes in ischemic myocardium mainly focuses on utilizing this delivery system to target and regulate local inflammatory responses, aiming to improve cardiac damage after ischemia. In ischemic myocardium, tumor necrosis factor-alpha (TNF-α) serves as an important inflammatory mediator involved in cardiomyocyte apoptosis and inflammatory responses. Therefore, the use of anti-TNF-α antibodies has the potential to reduce inflammation and protect cardiomyocytes.
Gene Expression
Normal Tissue
Figure 1 Tonsil
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
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More Infomation
Specifications
- Potential Clinical Applications
- Early detection of atherosclerotic plaques, Ischemic myocardium in vivo
Product Composition
- Clone
- CB0006
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that has been specifically engineered to target tumor necrosis factor-alpha (TNF-α). TNF-α is a critical cytokine involved in systemic inflammation and plays a key role in various inflammatory diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNF
- Introduction
- This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
- Alternative Names
- Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin; TNF-Alpha; TNFSF2; TNF-A; TNFA; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F
- Full Name
- Tumor Necrosis Factor
- Gene ID
- 7124
- UniProt ID
- P01375
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
Tumor necrosis factor, soluble form: The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion.
- Protein Refseq
- NP_000585.2
- Function
- Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208).
Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).
Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819).
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| Gly-163LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
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| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
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| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
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| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
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| NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
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| NEUT-2054CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2054CQ) | Neut | Rat IgG1 |
| NEUT-2055CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2055CQ) | Neut, FC | Rat IgD |
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| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2057CQ) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
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| MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
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| MOR-4463 | Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) | FC | Rabbit IgG |
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| HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0677-CN | Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) | ELISA, Neut | Humanized IgG |
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| CAT | Product Name | Application | Type |
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| HPAB-J0247-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone AP024/YC); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-J0248-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone F6); scFv Fragment | ELISA, Neut | Human scFv |
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| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
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| HPAB-2679LY-F(E) | Mouse Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2679LY-F(E)) | ELISA | Mouse Fab |
| HPAB-2680LY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2680LY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-2681LY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2681LY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-AP214-YC-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-AP214-YC-F(E)) | ELISA | Human Fab |
| HPAB-N0266-YC-F(E) | Human Anti-TNF Recombinant Antibody (clone NOV005YC); Fab Fragment | ELISA, Neut | Human Fab |
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