Recombinant Llama Anti-TNF Single Domain Antibody (PABC-547) (CAT#: PABC-547)
This product is a recombinant Llama antibody that can recognize TNF. The antibody can antagonize the binding of TNF to its receptor.
Specific Inquiry
FuncS
Figure 1 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Bivalent VHH#1 (VHH#1-9GS-HSA VHH-9GS-VHH#1) construct versus phosphate-buffered saline (PBS) control.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
FuncS
Figure 2 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Results for all groups at week 10.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
Specifications
- Immunogen
- Human TNF
- Host Species
- Llama
- Type
- Llama VHH
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- PABC-547
- Applications
- FuncS, ELISA, Neut
- Related Disease
- Arthritis
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for ELISA, Functional Assay, Neutralization. For details, refer to Published Data.
Target
- Alternative Names
- TNF; tumor necrosis factor; TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody
Mouse Antibody
Chimeric Antibody
Rat Antibody
Humanized Antibody
Single-domain Antibody
Fc Glycosylation
Non-hyper Galactosylated
Sialylated IgG Glycan
Hyper-galactosylated
Recombinant Antibody
Chicken IgY Antibody
Neutralizing Antibody
Blocking Antibody
Rabbit Monoclonal Antibody
scFv Fragment Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010 | Anti-Human TNF Recombinant Antibody (TAB-010) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1, κ |
| TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
| TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
| TAB-119CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E)) | ELISA, BL | Human Fab |
| TAB-150CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-150CQ-F(E)) | ELISA, Neut | Human Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABC-547. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: Inhib, Cyt
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
![Figure 1 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in SDS-PAGE](https://img.creativebiolabs.net/productimages/COA-TAB-1611CL-F(E)-1.png)
Application: Depletion, FuncS
-1.png)
Application: WB, ELISA
Application: ELISA
Application: ELISA, IHC, FC, IP, IF, BL
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, IHC, Neut
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
