Recombinant Llama Anti-TNF Single Domain Antibody (PABC-547) (CAT#: PABC-547)

This product is a recombinant Llama antibody that can recognize TNF. The antibody can antagonize the binding of TNF to its receptor.

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FuncS

Figure 1 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.

Figure 1 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.

Bivalent VHH#1 (VHH#1-9GS-HSA VHH-9GS-VHH#1) construct versus phosphate-buffered saline (PBS) control.

Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.

FuncS

Figure 2 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.

Figure 2 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.

Results for all groups at week 10.

Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.


Specifications

  • Immunogen
  • Human TNF
  • Host Species
  • Llama
  • Type
  • Llama VHH
  • Specificity
  • Human TNF
  • Species Reactivity
  • Human
  • Clone
  • PABC-547
  • Applications
  • FuncS, ELISA, Neut
  • Related Disease
  • Arthritis

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The antibody was validated for ELISA, Functional Assay, Neutralization. For details, refer to Published Data.

Target

  • Alternative Names
  • TNF; tumor necrosis factor; TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Chimeric Antibody

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TAB-006 Anti-Human TNF Recombinant Antibody (Infliximab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-148CQ Anti-Human TNF Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-402CQ Human Anti-TNF Recombinant Antibody (TAB-402CQ) ELISA Chimeric (mouse/human) IgG
TAB-148CQ-S(P) Anti-Human TNF Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-148CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)

Rat Antibody

CAT Product Name Application Type
TAB-623CL Bovine Anti-TNF Recombinant Antibody (TAB-623CL) Neut Bovine IgG

Non-hyper Galactosylated

CAT Product Name Application Type
Gly-083LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-085LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-163LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0609MZ Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY Indirect ELISA, WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2057CQ Rat Anti-Tnf Recombinant Antibody (clone XT3) Block, ELISA, IHC, WB Rat IgG1
NEUT-2070CQ Mouse Anti-TNF Recombinant Antibody (clone 4F4) Block, ELISA, ICC, IF, IHC, WB Mouse IgG1
NEUT-2071CQ Rabbit Anti-TNF Recombinant Antibody (clone 6E10) Block, ELISA, IHC, WB Rabbit IgG1
NEUT-2082CQ Mouse Anti-TNF Recombinant Antibody (clone B-C7) Block Mouse IgG1

Neutralizing Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-768 Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-006 Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-010 Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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