Mouse Anti-TNP Recombinant Antibody (clone IGELb4)
CAT#: FAMAB-0288YC
IgE immune responses to a variety of environmental and synthetic agents are the hallmark of certain allergic diseases that affect 5-15% of the population. Provided herein is a antibody against trinitrophenyl (TNP).
Published Data
FuncS
Figure 1 Groups of three to five F1 mice were immunized with SRBC-TNP and HRBC preincubated with 0–50 μg of IgE anti-TNP (IGELb4) (solid circles) or IgG2b anti-TNP (1B4) (open circles). Five days later the direct SRBC-specific (solid line) and HRBC-specific (broken line) PFC/spleen were assayed.
Karlsson, M. C., Wernersson, S., de Ståhl, T. D., Gustavsson, S., & Heyman, B. (1999). Efficient IgG-mediated suppression of primary antibody responses in Fcγ receptor-deficient mice. Proceedings of the National Academy of Sciences, 96(5), 2244-2249.
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgE
- Specificity
- TNP
- Clone
- IGELb4
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- TNP; 2,4,6-trinitrophenol; Picric acid
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Customer Review
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Reliable and reproducible
I am very happy with the specificity of the Mouse Anti-TNP Recombinant Antibody (clone IGELb4). It increased the reliability and repeatability of our immunological assays. The isotype compatibility provided a substantial advantage for our experimental requirements.
No cross-reactivity
Clone IGELb4's specificity for TNP is second to none. We haven't encountered any cross-reactivity issues, making this antibody an essential tool in our lab. It's great for any research focused on TNP-conjugated substances.
Easy storage and handling
Storage and handling of the Mouse Anti-TNP Recombinant Antibody (clone IGELb4) were straightforward, as detailed in the manual. The antibody maintained its integrity over multiple experiments, showing consistent performance. Truly a reliable product.
Q&As
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Could you describe the epitope recognized by the Mouse Anti-TNP Recombinant Antibody (clone IGELb4)?
A: The Mouse Anti-TNP Recombinant Antibody (clone IGELb4) specifically recognizes the 2,4,6-trinitrophenyl (TNP) hapten. This small molecule is commonly conjugated to various proteins for immunological studies, and clone IGELb4 binds to it with high affinity.
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What is the recommended storage condition for the Mouse Anti-TNP Recombinant Antibody (clone IGELb4)?
A: The recommended storage condition for the Mouse Anti-TNP Recombinant Antibody (clone IGELb4) is at -20°C for long-term storage. For short-term usage, aliquots can be stored at 4°C. Repeated freeze-thaw cycles should be avoided to maintain antibody integrity and performance.
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What is the clone IGELb4's isotype, and how does it affect experimental setup?
A: The Mouse Anti-TNP Recombinant Antibody (clone IGELb4) is of the IgG1 isotype. This isotype is commonly used in various immunoassays and is compatible with a wide range of secondary antibodies, facilitating easy incorporation into existing experimental setups.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# FAMAB-0288YC, RRID: AB_3111325)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone IGELb4"
- CAT
- Product Name
See other products for "TNP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G064R | Anti-TNP immunotoxin (IgM)-RTA | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0286YC | Recombinant Salmon Anti-TNP Antibody (1-01) | ELISA | Salmon IgG |
| FAMAB-0287YC | Mouse Anti-TNP Recombinant Antibody (clone IGELa2) | ELISA | Mouse IgE |
| MOB-398YC | Chimeric (Mouse/Human) Anti-TNP Recombinant Antibody (MOB-398YC) | ELISA | Chimeric antibody with human IgG1 Fc |
| VS-0625-FY1244 | Mouse Anti-tnp Recombinant Antibody (clone 2506W1139) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0286-YC-S(P) | Recombinant Salmon Anti-TNP Antibody scFv Fragment (1-01) | ELISA | Salmon scFv |
| FAMAB-0287-YC-S(P) | Mouse Anti-TNP Recombinant Antibody (clone IGELa2); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0288-YC-S(P) | Mouse Anti-TNP Recombinant Antibody (clone IGELb4); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0286-YC-F(E) | Recombinant Salmon Anti-TNP Antibody Fab Fragment (1-01) | ELISA | Salmon Fab |
| FAMAB-0287-YC-F(E) | Mouse Anti-TNP Recombinant Antibody (clone IGELa2); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0288-YC-F(E) | Mouse Anti-TNP Recombinant Antibody (clone IGELb4); Fab Fragment | ELISA | Mouse Fab |
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