Anti-YAP1 (clone W24V76) Recombinant Antibody Coupled Liposome (VS-1024-FY77) (CAT#: VS-1024-FY77)

• Potential Clinical Applications
• Breast cancer

• Clone
• W24V76

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant human antibody is specifically engineered to exhibit high binding affinity towards human YAP1 (Yes-associated protein 1). This antibody has been meticulously designed to recognize and attach to YAP1, a crucial regulator in various cellular processes, including proliferation, apoptosis, and organ size regulation. The specificity of this recombinant antibody ensures that it interacts exclusively with YAP1, minimizing cross-reactivity with other proteins.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• YAP1

• Introduction
• This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.

• Alternative Names
• COB1; YAP; YAP2; YAP65; YKI

• Full Name
• Yes Associated Protein 1

• Gene ID
• 10413

• UniProt ID
• P46937

• Sequence Similarities
• Belongs to the YAP1 family.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001).
  Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240).
  Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001).
  Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).
  Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.

• Protein Refseq
• NP_001123617.1; NP_001181973.1; NP_001181974.1

• Function
• Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097).
  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288).
  Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702).
  Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288).
  The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
  Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
  In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
  Isoform 2: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
  Isoform 3: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).

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