Human Anti-EBOV GP protein (clone 7H7) scFv-Fc Chimera (CAT#: VS-0125-FY115)
A human monoclonal scFv-Fc antibody targeting the glycoprotein (GP) of Zaire Ebolavirus has been developed. The envelope glycoprotein is processed into two subunits, GP1 and GP2, while the transmembrane and cytoplasmic domains have been eliminated. The immunogen includes a C-terminal linker and a hexahistidine tag sequence (GSGHHHHHH). GP1 plays a crucial role in binding to receptors on host cells, specifically interacting with CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are essential cofactors for viral entry. The binding of GP1 to CD209 on dendritic cells (DCs) and to CLEC4M on the endothelial cells of liver sinusoids and lymph node sinuses enhances the infection process of macrophages and endothelial cells.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Zaire Ebolavirus (EBOV)
- Clone
- 7H7
- Applications
- ELISA, Western Blot, Immunofluorescence
- Related Disease
- Zaire Ebolavirus (EBOV) infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 6.0
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Ebolavirus glycoprotein, EBOV glycoprotein
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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