Human Anti-WT1/HLA-A2 scFv-Fc Chimera (VS-0125-FY101) (CAT#: VS-0125-FY101)
The antibody was isolated from a human scFv phage display library, indicating that the cloning process involved the selection of specific single-chain variable fragments (scFvs) that exhibit high affinity for the WT1/HLA-A2 complex.
This product is a high-affinity TCR-like antibody suitable for the treatment of WT1-positive tumors. Due to its specificity and potency against tumor target cells, it may have potential for cancer immunotherapy.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The main function of this scFv is to specifically recognize and bind to the WT1/HLA-A2 complex. Subsequently, by utilizing a bivalent scFv-huIgG1-Fc fusion protein, the binding ability is further enhanced, which can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and promote the lysis of tumor cells.
Target
- Alternative Names
- GUD (Gene Upregulated in Cancer), Wilms tumor protein, WT-1 (Wilms tumor protein), KTS (the KTS isoform of the protein-WT1), WIT1, WILMS, WT33
- Sequence Similarities
- Belongs to the EGR C2H2-type zinc-finger protein family.
- Cellular Localization
- Nucleus
Nucleus, nucleolus
Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_000369.4; NP_001185480.1; NP_001185481.1; NP_001354783.1; NP_001393973.1
- Function
- Transcription factor that plays an important role in cellular development and cell survival.
Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'.
Regulates the expression of numerous target genes, including EPO.
Plays an essential role for development of the urogenital system.
It has a tumor suppressor as well as an oncogenic role in tumor formation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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