Mouse Anti-MHC II scFv-Fc Chimera (VS-0425-FY12)
CAT#: VS-0425-FY12
The anti-MHC II scFv-Fc is a recombinant protein that specifically targets major histocompatibility complex class II molecules, playing a critical role in modulating immune responses. This innovative product features a single-chain variable fragment (scFv) fused to an Fc domain, enhancing its stability and efficacy in therapeutic applications.
Specifications
- Immunogen
- The immunogen used to generate the clone was malignant lymphoma cells, specifically L428 and KMH-2 cell lines, these cell lines express MHC class II.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- It has a high affinity to the peptide sequence CRHNYGVGESFT within the HLA-DR52 β chain.
It also binds to at least one selected from amino acid sequence RNQKGHSGLQPRGFLS, amino acid sequence FFNGTERVRLLERHF, and amino acid sequence RHNYGAVESFTVQRR.
- Species Reactivity
- Human
- Applications
- Western Blot, Flow Cytometry, Cytotoxicity
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 10 μg/mL
Cytotoxicity: 3 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- MHC II; MHC class II molecules
- Long Name
- MHC class II molecules
- Function
- The MHC II genes encode for Major Histocompatibility Complex class II molecules, which are crucial cell surface receptors in the adaptive immune system. Primarily found on professional antigen-presenting cells (APCs) like dendritic cells, macrophages, and B cells, their main function is to present processed exogenous antigens (derived from outside the cell) to CD4+ T helper cells.
This process begins with the uptake and breakdown of foreign pathogens or extracellular material within APCs. The resulting peptide fragments are then loaded onto MHC II molecules within endocytic compartments. These peptide-MHC II complexes are transported to the cell surface, where they are recognized by specific T cell receptors on CD4+ T cells. This interaction leads to T cell activation, which is essential for orchestrating downstream immune responses, including B cell activation for antibody production and the activation of other effector cells to combat the infection. In essence, MHC II molecules bridge the gap between antigen recognition and the initiation of a targeted immune response.
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Related Diseases
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| FAMAB-1476CQ | Rabbit Anti-MHC II Recombinant Antibody (clone YKIX 334.2) | block, IHC, IP, FC | Rabbit IgG |
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