Recombinant Anti-SLC4A2 Vesicular Antibody, EV Displayed (VS-0425-YC50) (CAT#: VS-0425-YC50)
The Recombinant Anti-SLC4A2 Vesicular Antibody, EV Displayed (VS-0425-YC50) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SLC4A2-expressed cells or tissues. The SLC4A2 is an anion exchanger involved in intracellular pH regulation and linked to primary biliary cirrhosis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/if_selected.jpg
Figure 2 Placenta
(High expression in placenta)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_1_7_val_selected.jpg
(High expression in placenta)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_1_7_val_selected.jpg
Figure 3 Stomach
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_2_1.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_2_1.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_8_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19339/45142_A_8_3.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164889-SLC4A2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164889-SLC4A2
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SLC4A2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Rat, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Solute carrier family 4 member 2
- Biological Process
- Anion exchange, Antiport, Ion transport, Transport
- Cellular Localization
- Nuclear speckles, Plasma membrane, Cytosol
- Introduction
- This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]
- Alternative Names
- AE2, BND3L, EPB3L1, HKB3, NBND3
- Gene ID
- 6522
- UniProt ID
- P04920
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3062z | Mouse Anti-SLC4A2 Recombinant Antibody (clone 36G6) | WB, ELISA, IF, IP | Mouse IgG2a, κ |
| VS-0224-XY120 | Mouse Anti-SLC4A2 Recombinant Antibody (VS-0224-XY120) | ELISA, WB, FC, IF, IP, IHC-P | Mouse IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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