Recombinant Mouse Anti-USP11 Antibody (clone 2D7A11)
CAT#: VS3-FY1527
This product is a recombinant mouse antibody that recognizes USP11. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Flow Cytometry. The clone 2D7A11 is specific for USP11.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3103/1401_B4_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37536/79801_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37536/79801_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37536/79801_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102226-USP11
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Clone
- 2D7A11
- Applications
- Enzyme-linked Immunosorbent Assay, Western Blot, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Flow Cytometry.
Target
- Alternative Names
- Ubiquitin Specific Peptidase 11; Deubiquitinating Enzyme 11; Ubiquitin Thioesterase 11; UHX1; Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked; Ubiquitin-Specific Processing Protease 11; Ubiquitin-Specific-Processing Protease 11
- Gene ID
- 8237
- UniProt ID
- P51784
- Sequence Similarities
- Belongs to the peptidase C19 family.
- Cellular Localization
- Chromosome, Cytoplasm, Nucleus
- Protein Refseq
- NP_004642.2; XP_005272731.1; XP_011542290.1
- Function
- Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799).
Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799).
Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889).
Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726).
Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "USP11"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3803 | Rabbit Anti-USP11 Recombinant Antibody (clone DS3803AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1560-CN | Rabbit Anti-USP11 Recombinant Antibody (clone JM33-62) | WB, IF, IP, FC | Rabbit IgG |
| VS3-QX1221 | Mouse Anti-USP11 Recombinant Antibody (clone 1220CT620.193.189) | WB, FC | Mouse IgG1, κ |
| VS3-CJ1023 | Mouse Anti-USP11 Recombinant Antibody (VS3-CJ1023) | WB, FC | Mouse IgG1, κ |
| VS3-FY1528 | Recombinant Rabbit Anti-USP11 Antibody (clone R08-2D7) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2450 | Anti-USP11 Immunohistochemistry Kit | IHC |
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