Recombinant Rabbit Anti-USP11 Antibody (clone R08-2D7) (CAT#: VS3-FY1528)
This product is a recombinant rabbit antibody that recognizes USP11. This antibody has been reported for use in Western Blot, Immunoprecipitation. The clone R08-2D7 is specific for human, rat USP11. The antigen is human usp11 synthetic peptide.
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WB
Figure 1. Recombinant Rabbit Anti-USP11 Antibody (clone R08-2D7) in WB.
Western Blot analysis of USP11 in Jurkat, rat brain, Hela lysates using USP11 Antibody.
Specifications
- Immunogen
- Human USP11 synthetic peptide.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat USP11
- Species Reactivity
- Human, Rat
- Clone
- R08-2D7
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated
- MW
- Calculated MW: 110 kDa; Observed MW: 110 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Ubiquitin Specific Peptidase 11; Deubiquitinating Enzyme 11; Ubiquitin Thioesterase 11; UHX1; Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked; Ubiquitin-Specific Processing Protease 11; Ubiquitin-Specific-Processing Protease 11
- Gene ID
- 8237
- UniProt ID
- P51784
- Sequence Similarities
- Belongs to the peptidase C19 family.
- Cellular Localization
- Chromosome, Cytoplasm, Nucleus
- Protein Refseq
- NP_004642.2; XP_005272731.1; XP_011542290.1
- Function
- Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799).
Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799).
Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889).
Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726).
Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046).
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3803 | Rabbit Anti-USP11 Recombinant Antibody (clone DS3803AB) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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