Anti-AAK1 Products

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For Research Use Only. Not For Clinical Use.

Accelerate your pain and neuroscience research with high specificity recombinant antibodies to AAK1 from Creative Biolabs. Adaptor-Associated Kinase 1 (AAK1) regulates the early stages of clathrin-mediated endocytosis and is an emerging target for next-generation, non-opioid pain therapeutics. Creative Biolabs' premium anti-AAK1 recombinant antibodies will help you unlock its potential in this important therapeutic area, as well as its role in cellular trafficking.

AAK1: A Novel Kinase Target for Non-Opioid Pain and Neurological Disorders

Adaptor-Associated Kinase 1 (AAK1) is a serine/threonine kinase that is essential for the early stages of clathrin-mediated endocytosis, the process by which cells internalize receptors, transporters, and other surface-associated cargoes, as well as pathogens. The kinase regulates clathrin coat formation and uncoating by phosphorylating the µ2 subunit of the AP-2 adaptor complex. Genetic and pharmacological inhibition of AAK1 has recently been validated in pre-clinical studies as a novel, non-addictive approach to treating neuropathic pain. Targeting AAK1 is also being explored for use in other neurological and psychiatric disorders.

Alternative Names

AP2 Associated Kinase 1; EC 2.7.11.1; Adaptor-Associated Kinase 1; KIAA1048

Background

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Anti-AAK1 rAb Products

Our anti-AAK1 recombinant antibodies are optimized for precision and reliability. These high-quality antibodies are rigorously validated to specifically recognize AAK1, so you can be confident in using them to study expression, localization, and activity of this important therapeutic target with clarity and accuracy. With high affinity, low cross-reactivity, and robust performance in validated applications such as Western Blot and immunofluorescence, these rAbs will provide the high-quality, reproducible data you need to drive impactful research in this rapidly emerging therapeutic space.

Table 1. Featured anti-AAK1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages our flexible, proprietary platforms to produce our high-quality anti-AAK1 recombinant antibodies. We use optimized mammalian expression platforms as the foundation for most of our antibodies to ensure they are properly folded and modified, which impacts their native binding properties.

Featured Anti-AAK1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-AAK1 recombinant antibody production.

Fig.2 Gram-scale anti-AAK1 recombinant antibody production.

rAb Modalities

Creative Biolabs is accelerating discovery in this exciting therapeutic area by offering multiple customizable antibody formats. We have full-length IgGs that can be used in a broad range of immunoassays, as well as engineered antibody fragments that can help researchers all over the world better understand this novel therapeutic target.

Fig.3 Full-length anti-AAK1 recombinant antibody production and modalities.

Explore the exciting biology of AAK1 with a high-performance antibody from Creative Biolabs. Our recombinant antibodies are designed with high specificity, are rigorously validated, and come with the exceptional lot-to-lot consistency needed to be an ideal tool for pain and neuroscience research. Put your confidence in Creative to help power your next breakthrough. Reach out to us today!