ACE

Enables metallocarboxypeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including angiotensin maturation; cell proliferation in bone marrow; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease; autoimmune disease; gastrointestinal system cancer; heart valve disease; and lung disease. Orthologous to human ACE (angiotensin I converting enzyme).