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AIF1

Anti-AIF1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
Predicted location

Intracellular

Single cell type specificity

Group enriched (Kupffer cells, Hofbauer cells, Macrophages, Langerhans cells, monocytes)

Immune cell specificity

Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, neutrophil, myeloid DC)

Cell line specificity

Group enriched (HEL, HMC-1, NB-4, THP-1, U-937)

Interaction

Homodimer (Potential). Monomer. Interacts with LCP1.

Molecular function

Actin-binding

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