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ALOX15B
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes, Alveolar cells type 2, Squamous epithelial cells, Kupffer cells, Prostatic glandular cells, Basal respiratory cells)
Immune cell specificity
Group enriched (myeloid DC, classical monocyte)
Cell line specificity
Cell line enhanced (HHSteC, HSkMC, hTCEpi)
Molecular function
Dioxygenase, Oxidoreductase
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