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ANAPC1
Anti-ANAPC1 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC
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- PE-A*01:01/Human ANAPC1 (YVDHYYRDY) MHC Tetramer (MHC-LC4466)
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- Class: Class I
- Antigen: ANAPC1
- Antigen Species: Human
- Peptide: YVDHYYRDY
- Conjugate: PE
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- PE-A*69:01/Human ANAPC1 (YVDHYYRDY) MHC Tetramer (MHC-LC4467)
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- Class: Class I
- Antigen: ANAPC1
- Antigen Species: Human
- Peptide: YVDHYYRDY
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
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