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ANXA2
Anti-ANXA2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, FDA approved drug targets, Plasma proteins, Transporters
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Basal respiratory cells, Pancreatic endocrine cells, Prostatic glandular cells, Urothelial cells)
Immune cell specificity
Group enriched (basophil, myeloid DC, classical monocyte, non-classical monocyte, intermediate monocyte, T-reg)
Cell line specificity
Low cell line specificity
Interaction
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH (PubMed:21886777). Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458). Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (PubMed:14522961). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (PubMed:28669632). (Microbial infection) Interacts with human cytomegalovirus (HCMV).
Molecular function
RNA-binding
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