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ATG7
Anti-ATG7 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, IHC
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- Rabbit Anti-ATG7 Polyclonal Antibody (MRO-1654-CN) (MRO-1654-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC, FC
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- Rabbit Anti-ATG7 Recombinant Antibody (clone CBACN-037) (MRO-0109-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Astrocytes, Oligodendrocytes, Microglial cells, Late spermatids)
Immune cell specificity
Group enriched (classical monocyte, neutrophil, eosinophil, myeloid DC, intermediate monocyte, non-classical monocyte, basophil)
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:11096062). Interacts with ATG3 and ATG12 (PubMed:11096062, PubMed:11825910). The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5 (PubMed:11825910). Forms intermediate conjugates with ATG8-like proteins such as GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A (PubMed:11096062, PubMed:16303767). Interacts with EP300 acetyltransferase (PubMed:19124466). Interacts with FOXO1 (PubMed:20543840).
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