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BACH2
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For Research Use Only. Not For Clinical Use.
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Inhibitory neurons, Oligodendrocytes, Horizontal cells, Oligodendrocyte precursor cells, Excitatory neurons, B-cells, Astrocytes)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Group enriched (Daudi, U-698)
Interaction
Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
Molecular function
Activator, DNA-binding, Repressor
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